Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'We have identified a neural circuit for innate male sexual behavior (Figure 7U). This circuit enables recognition of potential mates and motor displays of mating, rejuvenates sexual drive, and makes mating rewarding. Moreover, our findings show that the brain employs distinct neural circuits to generate male mating and aggression.'
#Neuroscience
https://www.cell.com/cell/fulltext/S0092-8674(23)00798-5#gr7
"People watch a wildfire in Aljezur, Portugal, on August 7, 2023.
Pedro Nunes / Reuters"
https://www.theatlantic.com/photo/2023/08/photos-of-the-week-foam-party-pet-dryer-hummingbird-care/674983/
'Fifty years ago this month, the best-selling novel and the best-selling nonfiction title in the country had something unusual in common: They were both illustrated.'
https://www.nytimes.com/2023/08/10/books/review/joy-of-sex-breakfast-of-champions.html
"Here, we show that key metabolic functions of human hepatocytes are controlled by non-parenchymal cells (NPCs) in their microenvironment. We developed mice bearing human hepatic tissue composed of human hepatocytes and NPCs, including human immune, endothelial, and stellate cells. "
https://www.cell.com/cell/fulltext/S0092-8674(23)00795-X?dgcid=raven_jbs_aip_email#%20
Word of the day: "If the traveller had scaled the peak of phonolithic rock - so called because of the xylophonic sound the stones make as they slide away under a climber's feet (...)"
Graham Robb, The Discovery of France.
It's early & I haven't had coffee yet, but bear with me: is it conceivable that the Roberts Court has done the right thing?
"US Supreme Court halts $6bn Purdue opioid settlement in blow to Sacklers"
https://www.ft.com/content/5af08faf-1b87-47fa-b78d-4ff29eeebe4f
"Maps 12 & 15 von Willebrand Collection Vault map (12) and inset (15) (Dresden, Germany, 1919?).
(...) von Willebrand lived to the age of 97, finally expiring at a spa outside of Kaiserslautern, an obscure minor nobleman who never escaped his internal exile to the provinces. He died in the same year as the Weimar Republic, in 1933. The Margrave’s ill-advised attempt to keep up with the times led to the von Willebrand vault map’s misidentification as Degenerate Art. As a result, almost all copies were destroyed by the newly established Reich Chamber of Culture. Only the original copper plate matrix of the vault map remained untouched in the Sophienkirche annex, together with a pair of printed copies. The church was comprehensively destroyed during the Allied bombing of Dresden in 1945. Incredibly, a controlled detonation of unexploded ordinance in the immediate postwar period led to the unearthing of the vault map plate and a pair of prints in pristine condition"
#print #prints #printmaking #copperprintmaking #copperprint #art #handmade #maps #cartography #artgallery #artmastodon
'While moving upwards the intestinal villi enterocytes acquire different cellular fates, which is promoted by a gradient of Bmp ligands. In addition to this gradient individual Bmps have distinct activities in the differentiation of enterocytes.'
Berková et al @emboreports
''Lymph nodes (LNs) are critical sites for shaping tissue-specific adaptive immunity. However, the impact of LN sharing between multiple organs on such tailoring is less understood. Here, we describe the drainage hierarchy of the pancreas, liver, and the upper small intestine (duodenum) into three murine LNs.''
https://www.cell.com/immunity/fulltext/S1074-7613(23)00321-7
"They have investigated the brains of ageing mice, elucidating the source of the cGAS–STING trigger and the particular cells in which this pathway is activated (Fig. 1). Specifically, the authors find that cytosolic DNA derived from perturbed mitochondria activates the pathway in ageing microglia, the main immune cells in the brain — an observation that agrees with earlier findings that cGAS–STING is involved in activating microglia and in neuroinflammation"
#Immunology #Neuroimmunology #NeurodegenerativeDisease #InnateImmunity
'In contrast to the pathological activation of the immune system by metabolic stress, little attention has been paid to the physiological role of the immune system in regulating energy supply. In fact, the primary function of the immune system is to ensure tissue integrity and repair, thereby maintaining homeostasis.'
#Immunology & #Metabolism
https://www.cell.com/trends/immunology/fulltext/S1471-4906(23)00110-2
Benchmarking scATAC-seq
"Hence, an unbiased comparison of the use of different scATAC-seq methods on reference samples, and the resulting ‘benchmark data’, will allow researchers to make an informed method selection when considering scATAC-seq. Our study aimed to reduce ‘information asymmetry’ by equipping researchers with a comprehensive benchmarking of scATAC-seq tools, to increase the quality of data while reducing costs through informed decision-making."
"The Food and Drug Administration on Friday approved the first pill for postpartum depression, a milestone considered likely to increase recognition and treatment of a debilitating condition that afflicts about a half-million women in the United States every year."
https://www.nytimes.com/2023/08/04/health/postpartum-depression-pill-fda.html?action=click&module=Well&pgtype=Homepage§ion=Health
In April I wrote about how this new class of drugs were developed for #NatureMedicine. Read it at the link below:
'These findings suggest that an ancestral cRFXa homolog coordinated #ciliogenesis in the progenitors of animals and #choanoflagellates and that the selective deployment of the RFX regulatory module may have been necessary to differentiate ciliated from non-ciliated cell types during early animal evolution.'
#Evolution #CellBiology
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00929-6
'While extensive research has focused on mitochondrial dNTP homeostasis due to its defects being associated with various mitochondrial DNA (mtDNA) depletion and deletion syndromes, the investigation of mitochondrial rNTP homeostasis has received relatively little attention.'
#mitochondria
"This series consists of three-dimensional and collapsable (pop-up) collages, made inside cardboard boxes. The images used are engravings and illustrations found in a german encyclopedia published in the 1930’s.
Scales range from 15cmx21cm to 21x28cm."
It's summer in Portugal, so we are required by law to grill sardines.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
