Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
My latest clinical pipeline column for Nature Medicine is a look at a drug recently approved by the #FDA to delay the onset of type 1 diabetes.
It's a direct descendant of the very first monoclonal ever approved for clinical use.
#Diabetes #Type1Diabetes #DrugDevelopment #DrugDiscovery #NatureMedicine #Immunology #MonoclonalAntibody
👏 👏 👏
"A life-size bronze statue of Henrietta Lacks, the woman whose cancer cells were taken without her consent and were used for research that ushered medical discoveries and treatments, will be erected in her hometown, Roanoke, Va., next year in a plaza previously named after the Confederate general Robert E. Lee."
"The virus-neutralizing activity of antibodies can be readily defined in robust in vitro assays and in passive transfer experiments. But to what degree vaccination-induced humoral immune responses prevent infection and pathogen replication also in humans, and therefore serve as indicators or even correlates of sterilizing immunity, cannot be easily established."
Wahl & Wardemann on #SterilizingImmunity (from Oct).
https://www.cell.com/immunity/fulltext/S1074-7613(22)00558-1
Quinta dos Abibes Sauvignon Blanc, from Bairrada (near Coimbra). A small winery that we visited couple of years ago, I think this was the last bottle (they make a great sparkling, but those are long gone).
cc @BLMG
Great picture, from the NYT's "Year in Illustration" recap.
By Aleia Murawski and Sam Copeland for "Apocalypse When? Global Warming’s Endless Scroll"
https://www.nytimes.com/interactive/2022/12/13/arts/year-in-illustration.html
"William Hogarth’s Satire on False Perspective (1754), engraved by Luke Sullivan, offers an Escher-like array of impossible lines and vanishing points: a man lights his pipe from a distant candle; a flock of sheep grow bigger as they recede round a corner; a foreground flag disappears behind a distant tree, and many more."
This is such an important point in the comparative study of Toll like receptors and immunity across taxa: the prototypical Toll is *not* a microbial/foreign pattern recognition receptor, it is only activated by a host molecule.
"The Drosophila Toll receptor differs from the mammalian TLRs in that the Drosophila Toll receptor functions as a cytokine receptor (reviewed in Ref. 5), whereas the mammalian TLRs recognize foreign structures directly and thus are pattern recognition receptors (PRRs)."
'Es una pequeña pieza de bronce, no más grande que una bola de billar. Un poliedro de 12 caras que, en cada vértice, luce un pequeño remate redondo, como una esfera. En cada uno de sus planos hay tallado un agujero, y cada uno de estos agujeros resulta de distinto tamaño. Suena misterioso, y lo es. De los llamados dodecaedros romanos, de hecho, ni siquiera se sabe si tienen su origen en Roma. Ninguna referencia escrita alude a ellos, lo cual dificulta muchísimo interpretar qué lugar ocuparon en la sociedad cuando estos fueron aleados.'
"According to the art historian Charles Colbert, the usual practice of painters in this period ‘was to let the horizon fade into visual and conceptual insignificance’. But in Homer the horizon does not recede; it pitches forward, towards our world."
Elisa Tamarkin on #WinslowHomer at @lrb
https://www.lrb.co.uk/the-paper/v44/n24/elisa-tamarkin/at-the-national-gallery
"Differing from its predecessor, ENLIGHT has been designed and evaluated with two real-world clinical scenarios in mind: personalized oncology, where one matches the best treatment to a patient based on a fixed decision threshold, and CTD, where the goal is to a priori exclude non-responding patients in the best possible manner. "
#immunotherapy #Immunology #TumorImmunology #Biomarker #PersonalisedMedicine
https://www.cell.com/med/fulltext/S2666-6340(22)00455-X#secsectitle0105
"Ambiguity"?
'(...) in QAnon circles, Musk’s ambiguity and plausible deniability have been seen as a strategic way for him to subtly push their dogma into the mainstream. A QAnon-boosting account with 165,000 followers on Truth Social, Trump’s social network, wrote Monday: “At this rate, Elon is on pace to start posting Q drops to millions of normies and there’s nothing anyone can do to stop him.”'
https://www.washingtonpost.com/technology/2022/12/14/qanon-musk-revival-twitter/
Cancer, extrachromosomal DNA, and gene amplification
'Boosting the production of a protein is usually achieved by increasing transcription rates, but special cases can involve directly creating more copies of the associated gene (Stark and Wahl, 1984). This phenomenon was first identified in amphibian eggs, where it helps cells to produce the elements required for protein synthesis (see Tobler, 1975 for review).'
'At the Coal Face, 1942, by Henry Moore. Photograph: University of Manchester'
NB I hadn't realised that @biorxivpreprint also incorporated the possibility of adding a graphical abstract to the preprint page, kudos to @richardsever et al
I spoke with the senior author, Matteo Iannacone of #SanRaffaele in Milan for the #EMBOPodcast earlier this year about models for #SarsCov2 research, including dramatic differences between aerosol vs intranasal exposure to the virus in mice - the #pathogenesis of the disease is very different.
https://www.embo.org/podcasts/embo-young-investigators-past-and-present/
'SARS-CoV-2 infection has caused a major global burden. Despite intensive research, the mechanism and dynamics of early viral replication are not completely understood including the kinetics of formation of plus stranded genomic and subgenomic RNAs (gRNA and sgRNA) starting from the RNA from the first virus that enters the cell. We employed single-molecule RNA-fluorescence in situ hybridization (smRNA-FISH) to simultaneously detect viral gRNA and sgRNA in infected cells and carried out a time course analysis to determine the kinetics of their replication.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
