Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'Flagella-driven motility is essential for the entry of H. pylori into the mucus layer and for maintaining a swimming reservoir in the mucus (Fig. 3). H. pylori has a unipolar bundle of rotating sheathed flagella, with filaments composed of two flagellin proteins that evade activating the innate immune system via TLR5 due to specific adaptation of their amino acid sequences'
'In this review, we will briefly introduce the current treatment paradigms for PDAC and then expand upon the biological underpinnings driving its pathogenesis and progression.'
My latest Clinical Pipeline column for #NatureMedicine, on fitusiran, a small interfering RNA for the treatment of hemophilia A or B. It may be particularly useful for patients with inhibitors (antibodies against clotting factors).
#drugdevelopment #drugdiscovery #SciComm #sciencecommunication #pharma #hemophilia 👇
Frogs, glazed #stoneware by @hunchbacksociety
Richard Avedon and James Baldwin in Harlem, 15 October 1946 © Photograph by Richard Avedon © The Richard Avedon Foundation
https://www.ft.com/content/62a017eb-0ab6-449f-9d06-646c0bd42bc4
Neutrophil BM shuttle:
"We demonstrate how drug-loaded poly(lactic-co-glycolic acid) nanoparticles are taken up by neutrophils and are then transported across the bone marrow–blood barrier to boost drug concentrations in the bone marrow."
Not the BBC's finest hour (from The British Broadcasting Conundrum by Matt Seaton in NY Review of Books).
#newyorkreviewofbooks #bookshelf
It was a pleasure to reconnect with José Roberto de Toledo of Brazil's Piauí magazine a couple years after participating in his Portuguese language Pandemic Podcast, "Luz no fim da Quarentena" (ht @mucida).
On UOL's Análise de Notícia we talked about the new #malaria and #RSV #vaccines.
👇 Starts around min 27 (in Portuguese)
In December in the Clinical Pipeline column, I covered the FDA approval of the anti-CD3 teplizumab for a novel use: the prevention of type 1 diabetes for individuals at high risk.
Sanofi has just announced that it will buy the company making the drug, Provention Bio, for $2.9 billion.
https://www.sanofi.com/en/media-room/press-releases/2023/2023-03-13-06-00-00-2625367
'The new dogma is that bacteria have a pervasive (yet variable) presence within and across solid tumors—the ”presence of intratumoral bacteria being designated a hallmark of cancer.”
https://erictopol.substack.com/p/the-fascinating-and-evolving-story
'La Alhambra era una mezcla de ruina, espacios reconstruidos en épocas anteriores con un aire arabesco artificial que correspondía más a una versión idealizada de lo árabe que a la realidad del arte musulmán oriental propio de la Península. Era, en fin, un monumento en un equilibrio difícil a punto de caer del lado de la hecatombe'
https://elpais.com/cultura/2023-04-16/cuando-la-alhambra-era-una-ruina.html
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
