Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"In Japan, “The Tale of Genji” has maintained an unwavering grip on the culture. Passages are taught to most schoolchildren. It has been subjected to countless translations, interpretations and adaptations across seemingly every possible art form: paintings, Noh plays, dance, film, television drama, manga, anime, even a rom-com."
https://www.nytimes.com/2023/04/15/books/tale-of-genji-japan-women.html
The Kangaroo, #OgdenNash (fm "Candy is Dandy")
A new preprint from Ainsley Lockhart & @mucida has, as the cool kids say, just dropped:
"Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells"
#immunology #MucosalImmunology #preprint
https://www.biorxiv.org/content/10.1101/2023.04.11.536475v1?med=mas
For Throwback Thursday, an #EMBOPodcast episode with Akiko Iwasaki at the start of Covid year 2 (2021). We talked about the pandemic of course, but a lot more. Including her Immunology course at Yale.
"Ruslan (Medzhitov) and I have worked together to construct a course of introductory #immunology for medical students over the last several years. We wanted to approach immunology from first principles, not throwing some CD numbers and IL-whatever at the students, but really starting form how the system is established, how it works, what detection systems there are, and the arsenal of immune effector functions that are used to fight infection."
https://www.embo.org/podcasts/the-right-place-at-the-right-time/
Combining mRNA vaccines designed to boost T (including non-spike targets on nucleocapsid, membrane & ORF1ab proteins) and B cell responses (targeting the spike).
Merck’s has posted the full trial results for its first-in-class activin inhibitor for the treatment of pulmonary arterial hypertension, sotatercept. The final report supports last fall’s positive interim analysis, which I covered in the Clinical Pipeline.
The final analysis was just published in NEJM 👇
https://www.nejm.org/doi/full/10.1056/NEJMoa2213558
You can read my piece on it here
"Transcriptomic analysis of skate developing fins revealed a major reorganization of signalling gradients relative to other vertebrates1. The redeployment of developmental transcription factors, such as 3′ hox genes, initiates an anterior signalling centre analogous to the posterior apical ectodermal ridge (AER). These changes arose ~286–221 million years ago (Fig. 1b) after the divergence between sharks and skates. Nevertheless, the genomic and regulatory changes underlying these novel expression domains have remained elusive."
#EvoDevo
The topic of my latest #NatureMedicine Clinical Pipeline column, zuranolone, represents an improvement in both safety & ease of administration over its on its predecessor, brexanolone (which was the first drug approved specifically for postpartum depression in 2019). The case for it in major depressive disorder is more complex.
"Maps 6 & 9. The Origami Maps (Dresden, 1914-1918)
These maps, or objects, represent the sole known instance of an attempt at creativity by the Margrave. Like so many Europeans of his generation, von Willebrand was enthralled by Japanese art, and he developed a particular fascination with origami – a set of techniques with ancestral origins in Japan whose basic principles influenced the “folds of truth, folds of life and folds of beauty” ideas of German pedagogue Friedrich Fröbel.
Tragically, von Willebrand brought his newfound creativity to bear on the problems of cryptography – the Margrave was ever mindful of his duty to the Fatherland. von Willebrand’s work on the tactical applications of origami in the battlefield somehow managed to pique the interest of the Kaiser’s father, Frederick III, during his brief 99-day reign. When Frederick died, his relationship with the Margrave ultimately led his son Kaiser Wilhelm II to authorize a field test of the origami system during the Third Battle of Ypres. As a result, an entire German reconnaissance platoon was picked off one by one by a perplexed British sniper as they tried to fold paper while wearing full anti-gas gear."
#prints #Printmaking #cartography #handmade #artmastodon #artgallery #origami #origamiart
Single cell RNAseq atlas of the human bone marrow
Capt Louis is shocked. Shocked!
"The mogul’s treatment of union organizers and whistleblowers suggested that “free-speech absolutism” was mostly code for a high tolerance for bigotry toward particular groups, a smoke screen that obscured an obvious hostility toward any speech that threatened his ability to make money."
"In this study, we investigated the mechanism that one specific species of microbiota shortens lifespan and disrupts gut homeostasis of the aged flies, using a “fermented” fly diet. We found that the specific effects of this bacterium on fly healthspan were due to its capability of stimulating a specific receptor in the gut that recognizes peptidoglycan, a component of bacterial cell wall. Paradoxically, the same bacterium also increases stress resistance and defence against oral infection of a pathogen."
#Drosophila #Microbiota #ageing
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010709
'Our cross-species study indicates that scaling of cell size to ploidy is not due to abrupt changes in cell division timing, that different size scaling regimes occur during embryogenesis, and that the developmental program of Xenopus is remarkably consistent across a wide range of genome and egg sizes.'
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00161-6
Philadelphia’s 'Matisse in the 1930s' show is in Paris (l’Orangerie), will open in Nice in the summer.
'The exhibition fascinates as the first ever to focus on Matisse in this decade, for its optimistic account of renewal by an artist in his sixties and for European audiences as a rare chance to encounter tremendous paintings acquired by Americans.'
https://www.ft.com/content/4a5b1c3c-9e8c-4973-8fed-5bc9b0ec055a
My latest Clinical Pipeline column for #NatureMedicine is a look at zuranolone, a new antidepressant developed by Sage & Biogen, targeting the GABA pathway.
#drugdiscovery #drugdevelopment #depression #GABA #neuroscience
'We show here that in vitro exposure to SARS-CoV-2 activates the expression of the human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) in peripheral blood mononuclear cells from a subset of healthy donors, in ACE2 receptor and infection-independent manner.'
https://www.cell.com/iscience/fulltext/S2589-0042%2823%2900681-8
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
