Thiago Carvalho @cyrilpedia@qoto.org

'Why are we so fascinated by stories about sentient robots, rapacious A.I. and the rise of thinking machines? Faced with that question, I did what any writer on deadline would do and asked ChatGPT.'

https://www.nytimes.com/2023/02/22/movies/ai-movies-microsoft-bing-robots.html

#ceramics #ceramicsofmastadon #handmade #ArtMastodon
https://madalenaparreira.com/Hunchbacksociety

That turned out to be a very good move:

"In 1956 I reviewed for Virology a note by Groupé and Manaker reporting an assay of RSV in cell culture by production of transformed foci (21). A significant difference from my efforts to assay RSV in culture was their addition of tryptose phosphate broth to the medium. I enlisted Howard Temin, a first-year graduate student in embryology, to help in adaptation of the RSV focus assay to Dulbecco's monolayer assay of cytocidal viruses "

https://www.pnas.org/doi/10.1073/pnas.1108655108

Less is more for monoclonal antibody affinity?
(Particularly if deletion is not the goal)

"This approach delivered higher immune cell activation, in vivo T cell expansion and antitumour activity in the case of CD40. Moreover, an inert anti-4-1BB monoclonal antibody was transformed into an agonist. Low-affinity variants of the clinically important antagonistic anti-PD-1 monoclonal antibody nivolumab also mediated more potent signalling and affected T cell activation."

#Monoclonal #MonoclonalAntibody #immunology #drugdiscovery #drugdevelopment

https://www.nature.com/articles/s41586-022-05673-2

"Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo #FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas #th17
partially converted toward a regulatory phenotype in the injured myocardium."

#immunology #Treg

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322183

Belmonte.

At the CRG-Barcelona:

"The Severo Ochoa IMPULSE Visitor Program call is now open!

Apply if you would like to have access to the Core Technologies, Scientific Resources and Business and Development capacities available at the CRG. You will be hosted by CRG groups or Core Technology units and will integrate into the group activities."

https://www.crg.eu/en/content/careers-job-opportunities/impulse-2023

A #preprint with a new method that could allow detecting a mutation in its infant stage, when it's still just a mismatch:

"Here, we developed a single-molecule, long-read sequencing method that achieves single-molecule fidelity for single-base substitutions when present in either one or both strands of the DNA."

https://www.biorxiv.org/content/10.1101/2023.02.19.526140v1

A mysterious 1st century Roman tower just outside the town of Belmonte (Portugal) - no knows what it was: home, military watchtower, administrative building, trading center or something else entirely.

"And a grim report today in The Lancet and being presented at a conference in Seattle, which analyzes the death last summer in Mexico and the cases of 381 other mpox patients who also had advanced HIV infections, makes clear the disease poses an enormous risk to those living with uncontrolled HIV. Of the 179 patients with less than 200 CD4 cells per microliter—more than 500 is considered normal—27 died."

#monkeypox #AIDS #HIV #InfectiousDisease #InfetionImmunity

https://www.science.org/content/article/case-studies-expose-deadly-risk-mpox-people-untreated-hiv#.Y_VKFb_W9eA.linkedin