Johannes W. Dietrich @drjwdietrich@qoto.org

#Thyroid hormones play a pivotal role in #thermoregulation and the attunement to hot and cold #climate​s. Recent research found global patterns of variants in the UCP1 and UCP3 genes and #SPINA-GD (step-up #deiodinase activity), suggesting integrated adaptation.

https://doi.org/10.3390/biology14050454

Interestingly, both subclinical #hypothyroidism and #thyrotoxicosis predict #MACE. The free thyroxine (FT4) concentration is more associated with the HR for cardiovascular events than thyrotropin (TSH) levels. Our observations yield an integrated model including psychosocial and somatic mechanisms.

#Thyroid hormones profoundly impact the #cardiovascular system. They act at all levels, ranging from the tier of ion currents over cellular processes to the macroscopic levels of myocardial tissue and even the whole organism.

https://doi.org/10.3389/fcvm.2022.942971

https://pubmed.ncbi.nlm.nih.gov/36046184/

The #cardiovascular system is sensitive to #thyroid hormones. Even mild deviations of the free #thyroxine concentration from a (probably individual) optimum confer a significantly increased risk for #MACE (major adverse cardiovascular events).

https://doi.org/10.3389/fcvm.2022.942971

https://pubmed.ncbi.nlm.nih.gov/36046184/

Medical treatment of #hyperthyroidism, i.e. #thyrotoxicosis due to overproduction of #thyroid hormone, remains a challenge. We developed a new dosage methodology based on model predictive control (MPC), which is faster and more stable than the usual trial-and-error approach. https://doi.org/10.1016/j.ifacol.2025.03.041

Diabetes mellitus is common in hidradenitis suppurativa (acne inversa). Affected persons are faced with low insulin sensitivity (#SPINA-GR) and a lack of dynamic compensation via pancreatic beta-cell function (#SPINA-GBeta), resulting in a reduced disposition index (#SPINA-DI).

https://doi.org/10.3390/jcm14072145

Multiple studies have proven the impact of #endocrine #disruptor​s, e.g. #phthalates and #parabens, on #thyroid #homeostasis. It was unknown, however, that these effects depend on whether or not the included persons are fasting.

https://pubmed.ncbi.nlm.nih.gov/39826653/

https://doi.org/10.1016/j.envres.2025.120880

Weltweit und gleichzeitig radikalisieren sich Teile der Bevölkerung und driften nach rechts. Was ist die Ursache?

Neben maschineller Probaganda könnte auch der negative #Flynn-Effekt eine Rolle spielen, eine Intelligenzabnahme durch endokrine #Disruptor​en.

https://blog.endokrinologie.net/intelligenzabnahme-flynn-effekt-4157/

About 10% of hypothyroid patients have reduced quality of life despite normal TSH concentration under therapy with levothyroxine (L-T4). A new randomised, double-blind trial demonstrated better QoL under L-T4 + L-T3 compared to L-T4 alone.

https://pubmed.ncbi.nlm.nih.gov/39865226/

https://doi.org/10.1186/s12902-025-01840-4

Teilnehmer:innen gesucht! Klinische Studie zur Verbesserung der #Insulintherapie bei #Diabetes mellitus Typ 1.

https://www.klinikum-bochum.de/fachbereiche/innere-medizin/diabetologie/insulin-studie.html

Digitale Zwillinge in der Endokrinologie: Der Weg zu einer prädiktiven und personalisierten Medizin. 🧪🩺

https://blog.endokrinologie.net/digitale-zwillinge-in-der-endokrinologie-5717/

#Smartwatch​es mit nichtinvasiver #Glukosemessung, ohne Stich, zuverlässig und günstig? Zu schön, um wahr zu sein! Untersuchungen des Instituts für #Diabetestechnologie in Ulm legen den Betrug offen. Selbst auf einer Banane wird ein #Blutzucker "gemessen". 🩺🧪

https://www.ifdt-ulm.de/fileadmin/website/Video_Content/Smartwatches_deutsch2.mp4

Assessing diagnostic tools in #endocrinology with computer simulations https://link.medium.com/qDCugbiYZMb

Einladung zur 2. Endokrinologischen Abendsprechstunde "Up-to-date Schilddrüse 2024" am 25. September 2024.

#Schilddrüse #Nebenschilddrüse #Hypothyreose #Schilddrüsenchirurgie #Syndrom_T #SORSHOT

http://www.endokrinologie.org/resources/flyer-up-to-date-schilddruse-2024.pdf

#Metformin is a useful antidiabetic substance, but also an endocrine disruptor. A recent study shows that it reduces the set point of #thyroid homeostasis, but this effect is mitigated by #vitamin_D deficiency.

https://pubmed.ncbi.nlm.nih.gov/39204438/
https://doi.org/10.3390/pharmaceutics16081093

Which programming language is fit for high-performance computer simulations in biomedical #cybernetics? We found that #Free_Pascal generates faster code than S/R and #Python. Interestingly, Object #Pascal even outperforms #Swift and C++.

https://doi.org/10.14201/adcaij.31762

https://revistas.usal.es/cinco/index.php/2255-2863/article/view/31762

#Inflammation plays a key role in the pathogenesis of #diabetes mellitus. In our newest paper, we show that treatment of #hidradenitis_suppurativa (#acne_inversa) may cause remission of diabetes. CN: medical images in full text. https://pubmed.ncbi.nlm.nih.gov/39106221/ https://doi.org/10.1111/ddg.15490

#Xylitol consumption may have prothrombotic effects via platelet activation and thereby increase the risk for major adverse cardiovascular events (#MACE). 🧪🩺

https://pubmed.ncbi.nlm.nih.gov/38842092/

Die Grafen von #Neuburg-#Falkenstein waren ein bedeutendes Adelsgeschlecht der #Stauferzeit. Ihr Gebiet reichte von Oberbayern bis Südtirol und Niederösterreich. Ihre Stammburg #Unterfalkenstein wurde bei dem bayerischen #Hochwasser schwer beschädigt. #Klima

https://www.sueddeutsche.de/bayern/unwetter-nach-dem-hochwasser-plan-fuer-sicherung-an-burg-falkenstein-dpa.urn-newsml-dpa-com-20090101-240606-99-299157

Sensorimotor #polyneuropathy may be common in treated autoimmune thyroiditis, but, unlike in other causes of #neuropathy (e. g. #diabetes), it has a unique pattern in quantitative sensory testing (#QST) with low thresholds for mechanical and thermal pain.

https://doi.org/10.1038/s41598-024-63158-w