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Johannes W. Dietrich

Sektion , und am von der als Fußbehandlungszentrum (re-)zertifziert. endokrinologie.org lokalkompass.de/hattingen/c-ra

Sektion Diabetologie, Endokrinologie und Stoffwechsel am KKB von der Deutschen Diabetes-Gesellschaft als Fußzentrum (re-)zertifzierit. Im Bild: Nadine Schlottke, Dr. Daniel Quast, Dr. Assjana Abood, PD Dr. Johannes W. Dietrich und Dr. Bojana Bazika-Gerasch.
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Johannes W. Dietrich

Both SGLT-2 inhibitors and GLP-1 receptor agonists reduce cardiovascular risk () in type 2 mellitus, but they differ with respect to renal function. This may provide a more personalised approach to treatment.

pubmed.ncbi.nlm.nih.gov/373810 doi.org/10.1186/s12933-023-018

Comparison of absolute risk reduction for 3P-MACE according to baseline eGFR category in SGLT-2i or GLP-1RA
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Johannes W. Dietrich boosted
SPINA Team

In a prospective study including women with #euthyroid autoimmune #thyroiditis treatment with #vitamin_D increased #SPINA_GT, and therapy with selenomethionine raised #SPINA_GD, in parallel to improved #sexual function and reduced #depressive symptoms. doi.org/10.3390/nu15122815

Biochemical characteristics of the study population during the study
Percentage changes in titers of thyroid antibodies and levels of TSH, thyroid hormones and calculated structure parameters of thyroid homeostasis during the six-month period of diagnosis and during the study
Sexual functioning in the study population.
Depressive symptoms in the study population
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Johannes W. Dietrich

Herzlichen Dank allen Patient:innen und Kolleg:innen für die Empfehlungen, die zu meiner Listung beigetragen haben. pdf.focus.de/FOCUS-Gesundheit-

FOCUS Ärzteliste 2023
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Johannes W. Dietrich

Vorankündigung:
Hattinger Altstadtgespräch: – Was tun?

waz.de/staedte/hattingen/mediz

hattingen.de/stadt_hattingen/v

vhs.hattingen.de/index.php?id=

Hattinger Altstadtgespräch Osteoporose – Was tun? Johannes W. Dietrich
Hattinger Altstadtgespräch Osteoporose – Was tun? Johannes W. Dietrich 24.05.2023 ortho-mobile, August-Bebel-Str. 8, Hattingen
Hattinger Altstadtgespräch Osteoporose – Was tun? Johannes W. Dietrich
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Johannes W. Dietrich

Vorankündigung: und am 20. Hattinger Gesundheitstag "med in Hattingen" hattingen.de/stadt_hattingen/R

Schilddrüse und Herz: ein lebenswichtiger Zusammenhang
20. Hattinger Gesundheitstag "med in Hattingen"
Schilddrüse und Herz, PD Dr. med. Johannes W. Dietrich
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Johannes W. Dietrich

This confirms our previous theory that in severe cases of -19 a combination of positive and negative loops promotes oscillatory behaviour of viral load and immune system activity. pubmed.ncbi.nlm.nih.gov/361688 doi.org/10.1111/jep.13772…

The Janus‐faced role of interferons and a competition of positive and negative feedback loops determine the course of COVID‐19 infection. After binding to ACE‐2, SARS‐Cov2 is able to enter cells and to replicate. This initiates immune responses via B and T cells and interferon release, thereby reducing the virus load again. However, interferon alpha also stimulates the expression of ACE‐2, which facilitates virus entry and implements a positive feedback loop raising the global virus load.
Higher expression of the transmembrane serine protease 2 (TMPRSS2), as observed, for example, in males, stimulates the binding of SARS‐CoV2 to the ACE receptor and promotes a higher virus load. Simulation of the motif of combined positive and negative feedback loops suggests that higher TMPRSS2 expression may also give rise to oscillatory dynamics of the virus load, as previously observed in severe cases of COVID‐19.
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Johannes W. Dietrich

Severe -19 is a life-threatening condition, sometimes requiring extracorporeal membrane oxygenation () therapy. In our most recent study, we found that oscillatory inflammation heralds a poor prognosis. pubmed.ncbi.nlm.nih.gov/369910 doi.org/10.1038/s41598-023-319

(A–F): some laboratory parameters over time (mean)
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Johannes W. Dietrich boosted
SimulaBetaTeam

#SimulaBeta has been released in version 3.1.0 Challenger. This major upgrade introduces a plethora of new features. Probably the most important one is a load, reference and modulation sequencer (#LOREMOS) for the simulation of complex time series. simulabeta.sourceforge.io

SimulaBeta 3.1 Challenger on macOS 13.3 Ventura
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Johannes W. Dietrich boosted
SimulaBetaTeam

A handbook for SimulaBeta 3.1 is available from doi.org/10.6084/m9.figshare.22 or sourceforge.net/projects/simul

All versions (even future ones) can be downloaded via the permanent DOI
doi.org/10.6084/m9.figshare.22

Title page of the handbook for SimulaBeta 3.1
Page 6 from the handbook for SimulaBeta 3.1
Page 23 of the handbook for SimulaBeta 3.1
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Johannes W. Dietrich boosted
Scientific Pascal

The International Pascal Congress will take place in Salamanca from July 3rd to 7th, 2023. Early registration will end on April 10th. This congress will bring together science, technology and learners.

@Pascal_Congress
#Pascal programming #ObjectPascal

pascalcongress.com/index.html

International Pascal Congress. July 3rd to 7th, 2ß23. Salamanca, Spain
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Johannes W. Dietrich

Endocrine conditions are common in /#acne_inversa (HI). In our most recent study, we observed that 20% of patients with HI suffered from mellitus, mainly the MOD cluster of type 2 D – doubling the population prevalence.
doi.org/10.3390/ijms24076596

Excerpt of Table 1. Personal and diabetes mellitus-specific characteristics of HS patients.
Correlation analysis by Spearman rank coefficient between HbA1c levels and factors (n = 99).
Logistic regression with the dependent variable of diabetes mellitus and independent variables from the univariable analyses with a p-value ≤ 0.05 (n = 99).
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Johannes W. Dietrich

Systems biology of : Relational stability of two intertwined feedback loops protects concentration despite variations in 's secretory capacity. doi.org/10.1177/20420188231158

The hypothalamic–pituitary–thyroid (HPT) axis. The HPT axis consists of a network of feedback and feedforward loops that control the thyroid hormones FT4 and FT3.1 The upstream organs provide hierarchical settings and feedforward, namely, the hypothalamus to the pituitary via TRH and the pituitary to the thyroid gland via TSH. The thyroid feeds back to the pituitary and hypothalamus. FT4 is converted to the biologically more active FT3 through a multi-enzyme process, which is partly TSH-dependent. Both FT4 and FT3 provide feedback on TSH and TRH.
Sensitivities of FT3, FT4 and TSH to changes in the FT4 production rate. The fraction of the production rate of FT4 is denoted by v0. (a) If v0 decreases from 1 to 0, FT4 falls, while TSH rises simultaneously (due to reduced feedback by FT4 on TSH). FT3 does not decrease proportionally to FT4 (due to increased feedforward by TSH on FT3). (b) Conversely, if v0 increases from 1 to 15, FT4 increases, TSH decreases. Again, FT3 increases to a relatively lesser extent than FT4. (c) As v0 decreases (a), TSH increases from the normal to the hypothyroid range, but FT3 stays nearly unchanged despite a substantial change in its precursor FT4. (d) With increasing v0, TSH decreases, approaching its lower reference limit and FT4 levels rise substantially more, compared with FT3 levels.
Comparison of model predictions with clinical results. (a) In untreated patients (n = 357) with autoimmune thyroiditis (AIT) and subclinical hypothyroidism FT3 homeostasis was preserved, as the FT4–TSH ratio varied widely. In contrast, FT3 escaped from homeostasis in athyreotic patients (n = 77) with thyroid carcinoma on levothyroxine (LT4) replacement (Ca). The slopes in the two groups were statistically significantly different (non-linear general additive model, p = 0.02), as predicted by modelling. (b) The transition from thyroid health to severe hypothyroidism is modelled in a hypothetical case and clinically observed in individual patients. As the production rate of FT4 decreases (v0 = 0.0004–1), FT4 decreases while TSH increases, with the curve displaying a non-linear relationship between the two hormones. The points were measured in hypothyroid patients (different colour by patient id) post thyroidectomy prior to radioiodine treatment before commencing LT4 treatment.
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Johannes W. Dietrich

Derelicts.c20230313

Derelicts.c20230313
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Johannes W. Dietrich

Die und behandelt große Volkskrankheiten und und rettet täglich Leben. Dennoch ist sie gefährdet. In einer Stellungnahme betont die DGIM strukturelle und finanzielle Voraussetzungen für den Erhalt. dgim.de/fileadmin/user_upload/

Es gibt zahlreiche wichtige Querschnittsfächer in der Medizin (in der Inneren Medizin z.B. Endokrinologie/Diabetologie, Angiologie, Rheumatologie, Infektiologie). Diese Querschnittsfächer können nur bestehen, wenn deren strukturelle Anforderungen sicherstellt und in den Vorhaltekosten berücksichtigt sind. Dabei ist auch zu berücksichtigen, dass einige Fächer von einer weiteren Ambulantisierung besonders betroffen sind. Umso wichtiger ist es für diese Fächer, vor allem auch für die Weiterbildung im Fach, dass ihre Existenz an den Kliniken stationär und ambulant erhalten bleibt. Es ist zu fordern, dass Level III Krankenhäuser ein entsprechend zu definierendes breites Fächerspektrum vorhalten müssen, andererseits muss eine Finanzierungsgrundlage für diese Fächer geschaffen werden.
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Johannes W. Dietrich

Stellenausschreibung der Sektion Diabetologie, Endokrinologie und Stoffwechsel am KKB / UK RUB: Medizinische:r Fachangestellte:r mit Sekretariatsfunktion. Details: klinikum-bochum.de/karriere/st

Stellenausschreibung der Sektion Diabetologie, Endokrinologie und Stoffwechsel am KKB / UK RUB: Medizinische:r Fachangestellte:r mit Sekretariatsfunktion. Details: https://www.klinikum-bochum.de/karriere/stellenausschreibung-details/medizinische-fachangestellte-m-w-d.html
https://www.klinikum-bochum.de/karriere/stellenausschreibung-details/medizinische-fachangestellte-m-w-d.html
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Johannes W. Dietrich boosted
SimulaBetaTeam

#SimulaBeta 3.0.2 available. This version fixes some minor GUI bugs on all supported platforms. simulabeta.sourceforge.io/ doi.org/10.5281/zenodo.4922800 doi.org/10.5281/zenodo.7677361

SimulaBeta 3.0.2 on macOS 13.2.1 Ventura
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Johannes W. Dietrich

Real-world data confirm the benefit of continuous glucose monitoring (), as presented in Chantal Mathieu's opening lecture at pubmed.ncbi.nlm.nih.gov/337806

Slide of Chantal Mathieu's opening lecture at ATTD23 showing the benefit of continuous glucose monitoring (CGM) devices based on real-world data.
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Johannes W. Dietrich

@Veiel
Vielleicht sollte man den Kollegen darauf hinweisen, dass an den meisten (wenn nicht allen) Universitäten die Venia legendi wegen Unwürdigkeit entzogen werden kann.

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Johannes W. Dietrich

Vitamin D-Pillen – Segen oder Abzocke? swrfernsehen.de/betrifft/vitam

Gespräch zwischen PD Dr. med. Johannes W. Dietrich und einer Patientin im Rahmen eines Interviews für den SWR.
Sektion Diabetologie, Endokrinologie und Stoffwechsel: Nadine Schlottke bei der Blutentnahme bei einer Patientin im Rahmen von Filmaufnahmen für den SWR.
Universitätsklinik St. Josef-Hospital: Sektion Diabetologie, Endokrinologie und Stoffwechsel
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