DaveFinlayTCD @finlayd@qoto.org
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
Interesting 🤔. A common mechanism, located at the lysosome, linking amino acid and energy stress to organelle biosynthesis.
A few of my favourites in this one: #FNIP1 #AMPK #TFEB #mitochondria #mTORc1
Gut bacteria move into tumours and support immunotherapies by metabolising tryptophan to make indole-3-aldehyde.
More reasons to take care of your gut microbiome.
😬😬 not sure I have any gut bacteria left after 9 weeks iv antibiotics 😬😩
Lots of interest things in this paper but one thing that struck me was that:
"CD44 mediates the endocytosis of specific metals bound to hyaluronate, including copper".
A new transporter it would seem, at least to my knowledge anyway😁
How amazing are my ex PhD students @JesssicaW28 @loftusro @katiezyxw and @KediaMehta, who sent me this feel better soon package.
Including a mug with lab photos across the lifetime of the Finlay lab 🥰 and a lockpicking set - that’s an important skill to have 🤣
Thank you 😊
RT @MitoPsychoBio
How we think and talk about mitochondria matters to our science and to newcomers in the field.
The powerhouse analogy is expired and we need specific vocabulary to capture the beautiful complexity of mitochondrial biology.
We propose a framework and some nomenclature.
RT @laoneill111
Can’t beat statistics…Irish workers are the most productive in the world.
RT @kzernike
A 14-yo girl read The Exceptions and painted this picture as a tribute to Nancy Hopkins and her groundbreaking science. The artist’s mother, also a fan, presented this to Nancy last week.
Here’s to the future.
Don't you just LOVE when a paper comes out providing an explanation for a long term lab question 😀🎉 Mystery solved!!
This really nice paper just out in #PLOSpathogens
by @FirpoMason and @bryancmounce based at the Loyola University Chicago @LoyolaInDIRI. (a🧵)
Our Question?
RT @RyanLab_MBU
🚨Last weeks #immunometabolism discoveries🚨 @Bims_BiomedNews ⬇️⬇️⬇️
http://biomed.news/bims-imicid/2023-04-23
Highlights:
I) MYC-SLC7A5-glycolysis metabolic axis regulates MAIT cell proliferation & is impaired in obesity
II) Hypusination regulates SREBP2 translation & enterovirus infection
RT @UMassMetNet
Had a wonderful day with guest "Fluxing Star" Evanna Mills (sporting a MetNet T-shirt!) who's seminar on how metabolites function as signaling molecules was outstanding! Learn about Evanna and her amazing ability to hold a plank at the Metabolog - https://www.umassmed.edu/metnet/blog/2023/04/evanna-mills/
CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor
RT @AndyHogan82
Delighted to see our latest paper out in @scisignal - led by @KediaMehta & Marta Pisarska with superstar collaborator @LindaVSinclair - we go deeper on #MAITcell metabolism and the impact of obesity - https://www.science.org/doi/10.1126/scisignal.abo2709
RT @MiriamMerad
Excited to share our new paper in @NatImmunol on how TREM2+ monocyte-derived macrophages in lung cancer reduce activity of natural killer cells that fight tumors. We provide potential dual targeting strategies to improve antitumor immunity. Read here: https://rdcu.be/damS8
RT @McLoughlin_Lab
Fantastic research on show today @tcdTBSI for our annual celebration of Postgraduate research @tcdbi Congratulations to Roisin Lynch from @EdLavellee lab this years winner of the Tipton medal for postgraduate research also Erika Stewart from @TJRyan_77 lab a worthy runner up.
This is why ye want to release those cytotoxic granules directly at a target cell! 🤷♂️
NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection
RT @WHO
Pharaoh Ramses V comes to life. Watch this fascinating story about the eradication of a deadly disease. #SMALLPOX!
Did you know?
Following an ambitious 12-year global vaccination campaign led by WHO, smallpox is finally eradicated in 1980. 🙌
RT @NatImmunol
Interested in #quantitative_protein_expression? Check out a new community resource ImmPRes http://immpres.co.uk/ ImmPRes was created with the aim to provide an in-depth, high quality, quantitative map of the immuno proteome. See https://doi.org/10.1038/s41590-023-01483-4
RT @RafaJArguello
📢🙏 share and help us to find a motivated PhD candidate for an 🤯🤓🤩 opportunity at @CancerImmunoAMU
🧪🧠 Exciting #PhD call in #PediatricOncology! to advance #Medulloblastoma research using innovative single-cell metabolomic profiling! @SCENITHmetab #ImmunoMetabolism
1/
An interesting new double act!!
#Tcell immunotherapies engage #neutrophils to eliminate tumor antigen escape variants
I never thought I would be a #mitochondria nerd, but here we are 🤷♂️🤣. Gonna enjoy reading doing of these articles.
---
RT @CellPressNews
'The new @Molecular_Cell special issue focuses on the #mitochondria. The review articles in this issue focus on the diverse cellular processes involving mitochondria and the approaches used to study them. Take a look. https://hubs.li/Q01J2qN20
https://twitter.com/CellPressNews/status/1639328223816450048
We are an Immunometabolism research group that studies how nutrients and metabolism affect immune cell function at #TrinityCollegeDublin👨🔬 Love #NK_cells, #Dendritic_cells and #T_cells but can be easily convinced to talk at length about metabolism in any immune cell 😄. Twitter handle @DavidFinlayTCD
Joined Nov 2022
