I really like the idea of microPublications. This one is an intriguing observation:
https://www.micropublication.org/journals/biology/micropub-biology-000737
I’m sure many labs have some interesting results tucked away that suit this format.
Wow, we've reached new heights... just got a #spam email from a #predatory journal using anti spam-filter techniques straight out of the 90s... (which obviously work with the crappy spam filters our uni uses...)
I have created a little R #Shiny interface to deconvolute #luciferase assay data.
This is based on Brown 2008 - Inferring gene expression dynamics from reporter protein levels (but does not include volume correction)
The app also reports initial rate, maximum and decay rate
It is available here, for anyone to enjoy, modify etc
Anyone know a good review paper / learning resource for building gene regulatory networks #GRN from #scATACseq #ATACseq and/or #scRNAseq data?
Thanks!
It's time to vote for Inkscape's 1.3 About Screen Contest!
We're proud to present an amazing gallery of entries: 🖼️
54 entries by 43 #Inkscape artists!
Thanks to all who entered!
Community vote open from
Mar. 20 (0:00 UTC) to Mar. 26, 2023 (23:59:59 UTC). 🗳️
https://inkscape.org/gallery/=about-screen-contest/contest-for-13/
At the local primary school, the children sing a Mother’s day song with the lyric
“My mum’s ever so clever. She may not have a degree,
But she can help with my homework and that’s what matters to me.”
After many complaints the school have agreed to change the lyric (hooray!). To:
“… even though she’s got a degree,”
Which simultaneously makes having a degree sound bad and also shaming Mum’s without degrees.
Further damage to the dysfunctional academic career system in Germany: The government has just presented its reform of the fixed term contract law (#WissZeitVG).
After years of #IchbinHanna protests, the max. length of fixed contracts for postdocs has been reduced to 3 years. The cynical argument: Careers become more predictable, because 3 years after your PhD, it's either professorship, third party funding, or exit.
The lack of a broader tenure track system makes this a devastating development.
Oh, man. This comic — from 1993 — could NOT be more relevant today. As usual, Bill Watterson hits it out of the park.
RT @Apeer_micro
Learn how feature learning works in CNNs
Want to know the technique that gives #DeepLearning an edge over #MachineLearning?
Read our blog to find out.
https://hubs.la/Q01F6Nvp0
Ready to give Fedora Linux 38 a test? The beta release is here!
#Fedora #Linux #OpenSource
Learn more: https://fedoramagazine.org/announcing-fedora-38-beta/
Just finished reading this very interesting #review about #analysis of #scRNAseq data from different #species.
"Cross-Species Analysis of Single-Cell Transcriptomic Data" - Schafer - Front. Cell Dev. Biol 2019
https://www.frontiersin.org/articles/10.3389/fcell.2019.00175/full#B5
""The honors thesis must be a *single author* document written by the student."
Rules like this represent an antiquated approach to #science and harm the undergraduate researchers involved by teaching them that science is done by isolated individuals & that it's appropriate to not credit all contributors to a project.
Of course students should lead the work & writing of their honors thesis, but there's a difference between leading & doing it alone. We should teach science as it is practiced.
SMBC nailing it:
There is people out there thinking that computational biologists spend less time on scientific projects (not true) and therefore deserve less credit or even no authorship in papers, compared to wet lab people.
They clearly have never seen all the years and work that takes to gain the knowledge to do it. Just like they clearly do not value such a knowledge on lab work, since they only care about how many hours someone spend doing something.
Just reading this very interesting paper on how many #replicates are needed for appropriate analysis of bulk #RNAseq data and comparing tools for DE gene expression.
#bioinformatics #article #goodread
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878611/
From the abstract
With three biological replicates, nine of the 11 tools evaluated
found only 20%–40% of the significantly differentially expressed (SDE) genes identified with the full set of 42 clean replicates.
This rises to >85% for the subset of SDE genes changing in expression by more than fourfold. To achieve >85% for all SDE genes regardless of fold change requires more than 20 biological replicates.
Big thanks to all who contributed to these initial guidelines, including the helpful reviewers and editors!
‘According to the Retraction Watch database, the 200 authors with the most retractions account for over a quarter of all 19,000 retractions. Many of the most prolific fraudsters are senior scientists at big universities or hospitals.’
https://web.archive.org/web/20230222193709/https://www.economist.com/science-and-technology/2023/02/22/there-is-a-worrying-amount-of-fraud-in-medical-research
#fraud #science #academia
Senior lecturer at the Zhejiang-Edinburgh Joint Institute (ZJE) and Edinburgh University.
Undergraduate Programme Director, Biomedical Informatics at ZJE.
I teach #imageanalysis & #dataanalysis with #RStats & #python. I study #heterogeneity in #pituitary (and other) cells.
I'm also very interested in #reproducibility and #openscience.