Marco Radi @marcoradi@qoto.org

#introduction
Hello #ScienceMastodon,

I am a Group Leader at IGC Portugal, and also an Honorary Professor at UCL UK

In the lab, we like to call ourselves Optical Cell Biologists. We develop #Microscopy technology to study cells and their viral infection at the nanoscale. To do so, we deploy novel #SuperResolution and #MachineLearning methods

We hold an ethos for making our methods easily available, reproducible and open to anyone.

Post often about the lab, research we find cool and myself

Hello, World! First post here and sharing our newest #MedicinalChemistry #StructuralPharmacology study on the new 3rd gen EGFR inhibitor lazertinib. https://pubs.acs.org/doi/full/10.1021/acsmedchemlett.2c00213

Most importantly, new data from the LASER301 trial (plus others) have shown positive results for this drug compared to 1st gen gefitinib. https://twitter.com/StephenVLiu/status/1599066119842959360?s=20&t=E1fJR98imanS_5v9Rp84vQ

Our work reports structural and functional data detailing the molecular properties of this new clinically-effective targeted therapy.

Went a little quiet on Science Twitter in 2022 during the long process of migrating alone in your 30s, and have now emerged into a brave new world. Here we go.

#introduction: I am an immunologist in biotech working on #autoimmune diseases and #immunooncology. Postdocced in #primaryimmunodeficiency, PhD in #cytokines. Fascinated by the power of the #immune response in all its spheres.

Hoping to follow other scientists, doctors and patients combating immune diseases here!

My postdoc Katelyn Miller led this research, which surprisingly showed us that the plasma membrane SNARE protein SNAP23 is involved in generating EV-D68 RNA replication organelles. I love her work here because Katelyn showed that our original hypothesis (SNAP23 regulates entry or exit of virus) was *spectacularly* wrong!

https://www.sciencedirect.com/science/article/abs/pii/S0042682222002094

Few drugs for Alzheimer’s disease exist. Those that do exist offer minimal meaningful benefits
to patients with the disease.

It's worth considering why. 🧵(1/13)

So I guess I should do an introductory post. I am a Professor of Microbiology at University of the Pacific, interested in using genomics and imaging to understand biofilm formation and horizontal gene transfer. I am also a passionate fan of most forms of football (Rugby, American, and the Beautiful Game). I have been known to get political on social media from time to time...

A reminder of why we are trying to make a new and improved science community here on Mastodon.

Musk’s anti-Fauci tweet is my breaking point; leaving the other app behind so might as well do an #introduction!

I’m an Associate Professor of #Immunology at the #UniversityofWashington in Seattle. My lab studies programmed cell death in the context of cancer, infection and autoimmunity. Check out OberstLab.org for more info.

Outside the lab, I spend as much time as I can outdoors: Biking, rock climbing, hiking and #birding with my wife and our Irish Water Spaniel Rufus. What a good boy!

Today was the straw that broke the camel's back for me.

This morning Elon Musk tweeted that his pronouns were prosecute/Fauci.

You can’t study evolutionary biology under the roof of the Discovery Institute and you can’t have meaningful and productive scientific collaboration on a platform run by right-wing troll who denies science when its results are inconvenient to him and just simply to hear his audience cheer.

China’s COVID Wave Is Coming

https://www.theatlantic.com/health/archive/2022/12/china-zero-covid-wave-immunity-vaccines/672375

#China #COVID

'Most of Italy's schools lack mechanical ventilation systems. Instead, teachers are urged to keep windows open when weather conditions permit.

If the most efficient systems were installed "we could pass from 250 cases per 100,000 students (the alert level set by the education ministry) to a rate of 50 per 100,000," the Hume foundation and the Marche regional government said'

#Covid #Covid19 #PublicHealth

https://www.reuters.com/world/europe/italian-study-shows-ventilation-can-cut-school-covid-cases-by-82-2022-03-22/

Time for a proper #Introduction here: I am a #scientist working in #immunology. I am especially interested by how the immune system functions at barrier sites, during #autoimmunity, and how it is altered during #inflammation. I also strongly advocate for increasing scientific literacy, fighting #misinformation, promoting #equity , and prevent #ClimateChange

#Introduction.
I am a Senior Scientist @UW focusing on T cell #immunology interested in what constitutes the most beneficial T cell response to infection. Also fascinated by the complexities and oddities of non-mammalian immune systems.

Something people don’t know about me: In rare moments of quiet, I sketch (see work-in-progress pic).

I am here to keep up-to-date with the latest in science news, publishing, and banter. Might connect with the #indie music scene for some tunes too.

First post an a short intro. I’m a medicinal chemist/drug discoverer in academia. My group works on a variety of areas: cancer and neuroscience mainly. For (permanent) fun, when my students discover an in vivo probe, it gets tattooed on me. Can’t wait for our #PROTAC project to be successful, may need my leg.