Marco Radi @marcoradi@qoto.org

https://www.cnbc.com/2023/10/06/nobel-prize-winner-katalin-karik-on-being-demoted-perseverance-.html?__source=sharebar%7Ctwitter&par=sharebar

So many #wise words from #KatalinKariko

https://www.aargauerzeitung.ch/leben/interview-top-scientist-katalin-kariko-women-should-have-a-career-and-a-happy-family-ld.2352504

A #mentor who doesn't find time to correct trainees' writings (paper, thesis..) or delegate this kind of duty, is not mentoring you.

⚠️Warning signs: has no time for discussion or reads email when spoken to, unreachable when away, doesn't share info, says "me" instead of "us"

🔴A strong case for a long-hanging question!
A monumental #DrugDiscovery #perspective on #JMedChem.
Well done @arash4sadri 👏
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01737?ref=pdf

Submitted a #manuscript to an #Elsevier journal that brags 4 weeks of reviewing time: no feedback after three months, no replies to author's query email or from customer support and no possibility to unsubmit the manuscript.
Anyone with a similar experience?

"eHydrogenation:Hydrogen-free Electrochemical Hydrogenation!" by Kevin Lam et al. (@kevin) published in #Angewandte #Chemie. A practical and selective #electrochemical #hydrogenation and #deuteration (using D2O)! #openacces #chemistry #electrochemistry
https://onlinelibrary.wiley.com/doi/10.1002/anie.202309563

#Click #electrochemistry for the rapid modification of virus, bacterial and cell surfaces by Gouin Sebastien et al on #Nature #Communications https://www.nature.com/articles/s41467-023-40534-0.epdf?sharing_token=OsorvNCu4Dj2W8fEWjiX5NRgN0jAjWel9jnR3ZoTv0OkDjrrak_6vx-dAvbDcyZ3cXUi4a566YU_F8_4kqBUHQX1uGPIOvWqTjE2TLhmzCkk6pVMClBhNeLzBGxFusztvHgkCMpFZYPjkQH3T83mMMDsc01RfBwxbc7Ft61LbWw%3D

Something to try for a change...
#multitasking #research #grant #proposal

Nothing new under the sun, but it is always interesting to see how deep the rabbit hole goes....
#publishorperish #mdpi #pyramidscheme #metrics #impactfactor
https://english.elpais.com/science-tech/2023-06-04/a-researcher-who-publishes-a-study-every-two-days-reveals-the-darker-side-of-science.html

https://elifesciences.org/articles/88853

“I believe that you discover what you screen for, so screen design is of paramount importance and the high content nature of a phenotypic screen maximizes the chance of success whilst also identifying novel MOAs that can be challenging to anticipate.”

https://link.springer.com/article/10.1007/s00044-023-03070-6

Have big Pharmas stopped innovating?

https://www.nature.com/articles/d41573-023-00102-z

#Nucleoside #chemistry is where I started more than 20 years ago as a young MedChem student in the group of Maurizio Botta.
A back to the future adventure has brought us today to this new paper on #ChemMedChem.
We have tried to teach these old dogs new tricks for the development of #broadspectrum #antimicrobial agents.
#MedChem #DrugDiscovery #Antiviral
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300200

Call for proposals "MSCA@UNIPR BOOTCAMP 2023" – https://www.unipr.it/msca-bootcampunipr-2023 - aimed at selecting 20 postdoctoral researchers from all over the world who wish to submit innovative research projects for a Marie Skłodowska-Curie Actions Postdoctoral Fellowship.
Selected researchers will be eligible for a research grant up to 1,000 euro to participate in a training workshop that will be held in Parma from June 5th to June 7th, 2023.

https://pubs.acs.org/doi/10.1021/acscentsci.2c00456#.Y53U0aa5V7Q.twitter

NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.

https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#

🔴 The 3rd edition of the #COLOTAN #symposium will be held in #Parma 🇮🇹 on the 27th of January, 2023, entitled “#Gut #disorders and possible impact on #colonic #drug #targeting: An excursus on the most common #gastrointestinal disorders and on their potential effects on drug disposition.” #IBD

#Registration is #free but mandatory!
Would you like to contribute with a #poster? Please send your #abstract (max 1 page) to rabab.nasser(at)kuleuven.be

▶️ https://colotan-etn.eu/colotan-3rd-symposium-gut-disorders-and-possible-impact-on-colonic-drug-targeting/

Happy to share our just accepted #review on #multitarget approaches for the #synthesis of #purine and #pyrimidine derivatives. From the #prebiotic/#abiotic origin of life to new #green #chemistry strategies for #drugdiscovery.
https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ejoc.202201288?utm_source=google&utm_medium=paidsearch&utm_campaign=R3MR425&utm_content=Chemistry

A nice overview on #PCSK9 #inhibitors and related #medchem opportunities.
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.2c01290

#CUO246 from #Novartis is a promising DNA #gyrase/#topoisomerase IV dual #inhibitor active against Gram-positive and Gram-negative #bacteria.
https://journals.asm.org/doi/full/10.1128/aac.00921-22