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DGE young microscopists

ydge.de/

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DGE young microscopists

Our working group within the 🔬has a new team with new and old members. Have a look at our website:
ydge.de

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DGE young microscopists

Calling all budding ! 👩‍🔬 👨‍🔬 Don't miss our virtual International on May 7th, 2023 at 6 PM UTC via Zoom. Join us for relaxed conversations, online games, and a chance to win one of three raffle draw prizes sponsored by Thermo Fisher, MAS, and MSA. Register at forms.gle/MK4e7oPhYmuisGTw7. See you there! 🔬

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DGE young microscopists

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DGE young microscopists

It's the second day of . Especially as an early career scientist, you should not miss our later this evening at 18:15 (6:15 pm) in the room vanadium at darmstadtium.

Ph.D. student and expert talks 🥳

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DGE young microscopists

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DGE young microscopists

With the Microscopy Conference 2023 approaching, we would like to share ten tips for folks who are going to a conference for the first time.

1) Preparation:
1. Don't worry: A conference can be overwhelming, lots of people, large venue, many parallel sessions. But just observe and experience :)

2. Search the conference agenda for possibilities to connect to other students at Young Scientists events. These can be called student mixers and/or can be organized by the ‘youth association’ of the conference’s parent organization (eg. DGE/yDGE).

3. Look through the program and find out which sessions you definitely don't want to miss.

4. Dress code? It's a scientist's event, but it could be wise to look a bit more professional during your own presentation (sorts of 'smart casual', suits or costumes not needed)

a. If the question really gives you no peace: Check out the photos from past conferences in your field. You can usually get a good feeling on what the ‚dress code consensus‘ is.

5. You will usually walk around a lot: wear comfortable shoes

6. Can happen: venue is overly air-conditioned -> be prepared and bring a sweater or jacket

2) During the conference:
1. Find out where you will get food+beverages (lunchtime lectures, coffee breaks, shops around the venue)

2. Try to connect known names to faces.

3. Poster sessions are especially useful to make contact, and presenters are usually happy if you reach out to them. Simply saying that you're new to the field and asking if they can briefly say what their work is about is OK!

4. Remember: You are not the only first-timer at the conference!

🌐 📝

In addition, we would like to advertise our yDGE Symposium:

It will take place on 28/02/2023 from 18:15 until 20:15 in the Vanadium room.

Right after, we will also host a Social Networking Session. We are very much looking forward to connect with you in person in Darmstadt.

Do you have additional tips for conference newcomers? Please share them below!

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DGE young microscopists boosted
Virginie Uhlmann

Want to work at the intersection of morphometry and representation learning for bioimage analysis?

We have TWO open postdoctoral positions! Each comes with its own challenging biological question, unique dataset, and exceptional team of collaborators!

Details below👇

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DGE young microscopists boosted
Sjors Scheres

The identity of extra densities in #cryoEM maps of #amyloids from brains remains unknown, and a major focus of research. Just because a model fits in these fuzzy densities does not mean much, and writing speculative papers is going to be of little help.
biorxiv.org/content/10.1101/20

RNA as a component of fibrils from Alzheimer’s disease and other neurodegenerations

Fibrils from brains of patients with Alzheimer’s disease[1][1]–[5][2], Parkinson’s disease[6][3], amyotrophic lateral sclerosis[7][4] and other neurodegenerations[3][5],[4][6],[8][7]–[18][8] contain unknown molecules. Extra densities (EDs), containing these unknown molecules, are available to examine in electron cryo-microscopy maps from the Electron Microscopy Data Bank[19][9], a public repository. EDs can be visualised in their protein environments using matched atomic models from the Protein Data Bank[20][10], another public repository. Lysine-coordinating EDs from a wide range of neurodegenerative diseases[1][1]–[6][3],[8][7]–[18][8] and EDs from the glycine-rich region of TAR DNA-binding protein 43 (TDP-43) fibrils in amyotrophic lateral sclerosis with frontotemporal lobar degeneration (ALS-FTLD)[7][4] were the subject of the present study. EDs ran parallel to the fibril axis and at right angles to protein with a repeat distance matching that of protein. They formed connections with protein consistent with a role in the guided assembly of fibrils. They had a connectivity pattern and estimated molecular weights consistent with ribonucleic acid (RNA). A straight form of RNA (ortho-RNA, oRNA) was modelled into one ED. It fitted other EDs and formed a rich symmetrical network of hydrogen bonds when docked to protein, implicating RNA as a unifying and organising factor in neurodegeneration. A new hypothesis of neurodegeneration (ponc, protein ortho-nucleic acid complex, pronounced ponk) is proposed in which RNA is the driver of these diseases. According to the ponc hypothesis, a particular RNA sequence (likely repetitive) enciphers a particular strain of ponc agent with its own protein fold and type of neurodegeneration. Ponc provides an explanation of fibril growth and replication, species barrier and adaptation, inherited neurodegeneration, resistance to chemicals and irradiation, protein-free transmission and co-pathologies. Ponc may also be relevant to other chronic diseases and origins of life. New treatments might be possible, targeting the unique chemical and physical properties of ponc. ### Competing Interest Statement The authors have declared no competing interest. [1]: #ref-1 [2]: #ref-5 [3]: #ref-6 [4]: #ref-7 [5]: #ref-3 [6]: #ref-4 [7]: #ref-8 [8]: #ref-18 [9]: #ref-19 [10]: #ref-20

www.biorxiv.org
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DGE young microscopists boosted
Toma Susi

A collaborator of mine at TU Wien is looking for a postdoctoral research to join our joint project – fun with ions and and electron microscopy in 2D materials!

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DGE young microscopists boosted
Biology Open

Martha Montané-Romero et al. explore novel roles for #PLPP3 in #pluripotency exit and endodermal #differentiation in mouse embryonic stem cells:

journals.biologists.com/bio/ar

#Lipids #StemCells #YAP1 #HIPPO #DevBio #Development #Science #BiologyOpen #Biology #AcademicMastodon

Micrographs showing that embryonic stems cells lacking PLPP3 fail to differentiate endoderm in embryoid bodies.
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DGE young microscopists boosted
Brian English

a beautiful highlight of the microscopy by the Prevedel Lab: imaging 1.5mm into the brain #3Pmicroscopy #adaptiveoptics

nature.com/articles/d41586-023

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DGE young microscopists boosted
Hoang Anh Le (aka Anh), PhD

I have this silly question about #imagesegmentation. So is there any advantage to using different software for image segmentation? I see #ImageJ, #CellProfiler, #Napari and #Python all can do this, but if the underlying algorithm is the same, then why not just stick with ImageJ?

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DGE young microscopists boosted
Hao Yin

pushes VE-PTP (How?🤓) to downstream pole of , followed by endocytosis->⏫p-Tie2

Potentially explain how ⏫ &

Inhibition of VE-PTP by AKB-9785 fortifies & reduces Atheromas at atheroprone regions (aortic arch inner curvature, arch+intercostal bifurcations)🐭

Nice comparison of anti-leakage strategies
VE-PTP inhibition
Angpt1 activation of Tie2
Angpt2 inhibition

Dr. Donald McDonald & Dietmar Vestweber labs EMBO Mol Med 2023
embopress.org/doi/

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DGE young microscopists boosted
André Vatter | @avatter

Ich soll $42 bezahlen, damit ich ein Paper herunterladen darf, in dem untersucht wird, warum junge Wissenschaftler Papers lieber im Netz raubkopieren, anstatt dafür zu bezahlen.

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DGE young microscopists boosted
Open Microscopy Environment

RT: @svi_huygens@twitter.com

#microscopists, want to get a better overview of microscopy image #FileFormats, bit depth, scaling, image #metadata, dimensions, and more?

Join our webinar Feb 23 and explore what formats e.g. #OMETIFF:

svi.nl/WebinarInvitation

#microscopy #ImageAnalysis #confocal

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DGE young microscopists boosted
FocalPlane

On this #FluorescenceFriday we are mesmerised by the process of cilium disassembly.

Find out more about the role of CCDC66 in regulating cilium length and signalling in the @J_Cell_Sci paper from Ezgi Odabasi, Deniz Conkar, @CytoLab & colleagues.

journals.biologists.com/jcs/ar

#cellbio #microscopy #cilia

Also check out the tweetorial from Ezgi Odaba, which includes a movie showing assembly!

twitter.com/EzgiOdaba3/status/

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DGE young microscopists boosted
Centriolelab

RT @HoogendoornLab
We are recruiting a PhD student and/or postdoc! Are you interested in chemical biology, cellular signaling and the primary cilium? Look no further and come join us in beautiful Geneva 🇨🇭: hoogendoornlab.org/joinus Please RT!
@ERC_Research @unige_en @sciences_UNIGE

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DGE young microscopists

Time flies by. ⌛ One year ago, the DGE Young Microscopists (yDGE) were founded. In the first year, we set up a website www.ydge.de, 🌐 hosted our first social events and planned the first yDGE conference contribution 👔 (check out microscopy-conference.de/2/pro WS 3).

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DGE young microscopists boosted
Thomas Friedrich

Paper alert 🚨😊 (at #science & electron #microscopy folks)
After our riCOM paper(doi.org/10.1017/S1431927622000) we now published another #4D-STEM live reconstruction method. Here we use a Neural Network to reconstruct high-resolution phase images. It's all #opensource if u want to give it a go. 🙂
academic.oup.com/mam/advance-a

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