Luis M. Rocha @lmrocha@qoto.org

Awesome time visiting my PhD co-advisor and #legend Howard Pattee. #Respect for foundational work on #complexsystems #theoreticalbiology #hierarchytheory #multilevelcomplexity

Excited about this collaboration with Reka Albert 's lab, chiefly the work of Jordan Rozum with Felipe Costa and Kyu Hyong Park, just published in brand new PRX Life journal devoted to bridging the gap between physical and life sciences. Life is not after all at the #edgeofchaos? #complexsystems #systemsbiology

"In this study, novel metrics and simulations of experimentally-supported discrete dynamical models of cell processes reveal greater resilience to perturbation than previously observed, challenging the ‘edge of chaos’ theory for biological systems."

https://journals.aps.org/prxlife/abstract/10.1103/PRXLife.1.023009

Wonderful experience advising MS thesis of Miguel Bernardo Pereira @istecnico , with work conducted @IGCiencia and @BUSSIEDept on distance backbones of #complexnetworks. So rewarding to be spreading and expanding work initiated by George Klir, whose work I first heard about within these walls.

Graciela Gonzalez' great presentation of track 2 #biocreativeVIII at #AMIA2023 , focusing on multilingual symptom extraction from clinical text (BTW, less than 1% of published papers on EHR analyze text notes where much relevant medical information lies ). Missing @MKrallinger :)

Graciela Gonzalez, opening the Social Media Mining for Health 2023 (#SMM4H) at #AMIA2023, showing data for how social media data offers a great representative sample of population demographics.

Also, General findings of the shared tasks on #socialmedia mining. Pre-trained transformer models ruling. #AI #MachineLearning #AMIA2023 #SMM4H

Fall drive through Catskills and Hudson valley.

I am fascinated by the recent evidence showing that Polyplody may grant evolutionary advantages in the presence of drastic fitness changes (e.g. cataclysms):
https://www.science.org/content/article/cells-extra-genomes-may-help-tissues-respond-injuries-species-survive-cataclysms.

One option is that extra chromosomes may increase connectivity of gene regulatory networks--- fascinating work from van de Peer on that note: https://doi.org/10.1101/2023.04.28.538696, https://doi.org/10.1371/journal.pone.0220257.

The results are similar to ours a long time ago with RNA Editing , where we experimented with drastic fitness changes (simulated cataclysms) and emergence of memory: https://doi.org/10.1162/evco.2007.15.3.253, https://doi.org/10.1007/978-3-540-74913-4_7.

RNA Editing, we started arguing long ago, also adds additional regulatory variety and proves advantageous in drastic fitness changes---though RNA editing works by adding more variants, not greater number of regulatory possibilities (network connectivity) as it is hypothesized for polyploidy. Maybe this explains why the latter is maladaptive in stable fitness landscapes, whereas RNA Editing often isn't?

#Evolution #EvolutionarySystems #Polyploidy #Fitness #GenomeComplexity #Gemome

This Saturday. If you're in Lisbon. After 1am, @RoterdaoC Cais do Sodré, pink street. #disco #funk #house #synthwave #indie #techno

Epá, agora trabalho em esqueletos de Salvação. E eu que nunca fui em coisas góticas :) No Expresso
este fim de semana.
https://leitor.expresso.pt/semanario/semanario2627/html/primeiro-caderno/sociedade/o-futuro-do-futuro-1/esqueleto-de-salvacao

A praia de #Carcavelos está cheia de manchas de óleo além da espuma que a assola há vários dias. Não sei se a origem é a lavagem ilegal de depósitos de barcos na barra, ou o rio que ainda desagua na praia a céu aberto quando chove?

#BestOf2022 #music that made my radar. Top 40 Albums, Top 100 Tracks, Top 20 Remixes/Edits (from E-Trash's #DJ sets): https://bit.ly/CityZen22. The top tracks and remixes are assembled in a Spotify List as well: https://spoti.fi/3PSimS6.

2022 was a hardworking year, though full of fun travel and reconnection with friends and family---thank you vaccines! I was particularly delighted to get back to DJing to full clubs again. Every year is a great year for music, with such amazing tracks, even if perhaps fewer great albums. I am sure I missed really excellent stuff.

#photography

Bi-coastal hops.

@lamaral opening #complexnetworks 2022 with a thought-provoking keynote "An opinionated evaluation of where we are after a quarter century of complex networks“ in Palermo.