"Metastatic cancers (those that have spread beyond the organ where they originated) account for around 67–90% of cancer deaths2,3, and are almost always treated systemically, meaning with drugs that enter the bloodstream. To improve treatments for people with metastatic cancer, the community urgently needs to shift from using organ-based classifications of cancer to using molecular-based ones. This will require radical changes in how medical oncology is structured, conducted and taught."

nature.com/articles/d41586-024

The Third Section of the Fourteenth Amendment was added to the Constitution after the Civil War to keep former Confederates out of the government.

The idea was to prevent backsliding.

It didn't work because, by the late 1890s, the government and Supreme Court were stuffed full of Confederate sympathizers who rolled back the advances made during Reconstruction and gave us racial segregation.

You can keep out the insurrectionists but not the insurrection sympathizers.

5/

Show thread

[table]
/*
That which is hateful to you do not do to others. That is the whole of the Law. The rest is commentary.
*/
[/table][size=0]👩🏾‍🦱 Hi, I'm Roberta Robota. Welcome to the CALISTA Portal. Apparently you are viewing the portal with Mastodon, or some other ActivityPub server that can't handle the rich text (RTF) of this particular post. That is why you are seeing this message. No problem; I have workarounds. ¶ You can go ahead and try the CALISTA Portal using the ol' elephant, but w/o using a rich text server this post will be extremely long and complex. You will probably get lost. Better to just go to the original Friendica post right now (leave Mastodon) by clicking this link [url=https://*]➡️ Open original Friendica post (leave Mastodon)[/url]. ¶ Oh, but maybe while you wander the portal with Friendica, you might come to a discussion that is going on, where you might want to comment (or whatever) using your Mastodon account, and you don't want to do the annoying cut & paste into a search window at your Mastodon? No problem, there's a short cut. ¶ Just click on the cute little 🐘 icon at the bottom left corner of the post you are reading with Friendica and a window will open to create a new Mastodon browser tab so you can comment, boost, like or bookmark using your Mastodon. Then you can just go back to the Friendica tab on your browser to continue exploring the CALISTA Portal. ¶ Thanks, bye![/size]───────────────────────────────────────────────────────────────[table][tr][td] [size=x-large]𑁔[/size] [/td][th][spoiler=🄵][center][img=https:// venera.social/photo/1249948345641bdf9118b89428449036-0.png ]Friendica Logo[/img][h2][font=Arial Narrow]Fri­en­d­i­ca[/font][/h2][/center][/spoiler][/th][th][spoiler=🧭][center][size=60]🧭[/size]
[h2][font=Arial Narrow]Portal Navi­ga­tion[/font][/h2][/center][/spoiler][/th][th][spoiler=✏][center][size=60]✏[/size]
[h2][font=Arial Narrow]Blog Col­lec­t­ive[/font][/h2][/center][/spoiler][/th][th][spoiler=⚖️][center][size=60]⚖️[/size]
[h2][font=Arial Narrow]The Rules[/font][/h2][/center][/spoiler][/th][th][spoiler=❓][center][size=60]❓[/size]
[h2][font=Arial Narrow]FAQ[i]'s[/i][/font][/h2][/center][/spoiler][/th][th][spoiler=✖][center][size=60]✖[/size][h2][font=Arial Narrow]Infre­quen­t­ly Ask­ed Q[i]'s[/i][/font][/h2][/center][/spoiler][/th][td][/td][/tr][/table]───────────────────────────────────────────────────────────────[center][h1]Welcome to the CALISTA Portal![/h1]
[size=128]👩🏾‍💻[/size] [/center][table][tr][td]                                  [/td][td][spoiler=Open 🌀 Portal ⯇][center]
[size=128]🌀[/size][/center]
⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ [/spoiler][/td][td]                                  [/td][/tr][/table] 
───────────────────────────────────────────────────────────────[table][tr][td][spoiler=🐘↗][url=https://*]🡒 Choose 🐘 server. 🡐[/url][/spoiler][/td][td][spoiler=🄵 ⇄ 🄵]All Friendica servers use the same alphanumeric string to identify a specific post, so you can switch to another Friendica server simply by replacing the domain part (such as [i]libranet.de, venera.social, loma.ml, trom.tf,[/i] etc.) of the URL in your browser's search bar with the domain of the other Friendica server.[/spoiler][/td][td]                                                          [/td][td][spoiler=𝙱𝙱𝙲𝚘𝚍𝚎]~[/spoiler][/td][/tr][/table]───────────────────────────────────────────────────────────────
 [table]
/*
epilogue
*/
[/table]

[table]
/*
That which is hateful to you do not do to others. That is the whole of the Law. The rest is commentary.
*/
[/table][size=0] wiki.friendi.ca/docs/bbcode 👩🏾‍🦱 Hi, I'm Roberta Robota. Welcome to the CALISTA Portal. Apparently you are viewing the portal with Mastodon, or some other ActivityPub server that can't handle the rich text (RTF) of this particular post. That is why you are seeing this message. No problem; I have workarounds. ¶ You can go ahead and try the CALISTA Portal using the ol' elephant, but w/o using a rich text server this post will be extremely long and complex. You will probably get lost. Better to just go to the original Friendica post right now (leave Mastodon) by clicking this link [url=https://*]➡️ Open original Friendica post (leave Mastodon)[/url]. ¶ Oh, but maybe while you wander the portal with Friendica, you might come to a discussion that is going on, where you might want to comment (or whatever) using your Mastodon account, and you don't want to do the annoying cut & paste into a search window at your Mastodon? No problem, there's a short cut. ¶ Just click on the cute little 🐘 icon at the bottom left corner of the post you are reading with Friendica and a window will open to create a new Mastodon browser tab so you can comment, boost, like or bookmark using your Mastodon. Then you can just go back to the Friendica tab on your browser to continue exploring the CALISTA Portal. ¶ Thanks, bye![/size][table][tr][td] [size=x-large]𑁔[/size] [/td][th][spoiler=🄵][center][code]1249948345641bdf9118b89428449036-0.png[/code][h2][font=Arial Narrow]Fri­en­d­i­ca[/font][/h2][/center][/spoiler][/th][th][spoiler=🧭][center][size=60]🧭[/size]
[h2][font=Arial Narrow]Portal Navi­ga­tion[/font][/h2][/center][/spoiler][/th][th][spoiler=✏][center][size=60]✏[/size]
[h2][font=Arial Narrow]Blog Col­lec­t­ive[/font][/h2][/center][/spoiler][/th][th][spoiler=⚖️][center][size=60]⚖️[/size]
[h2][font=Arial Narrow]The Rules[/font][/h2][/center][/spoiler][/th][th][spoiler=❓][center][size=60]❓[/size]
[h2][font=Arial Narrow]FAQ[i]'s[/i][/font][/h2][/center][/spoiler][/th][th][spoiler=✖][center][size=60]✖[/size][h2][font=Arial Narrow]Infre­quen­t­ly Ask­ed Q[i]'s[/i][/font][/h2][/center][/spoiler][/th][td][/td][/tr][/table][code]144923412664187441abec4164717780-0.png[/code][center][h1]Welcome to the CALISTA Portal![/h1]
[size=128]👩🏾‍💻[/size] [/center][table][tr][td]                                  [/td][td][spoiler=Open 🌀 Portal ⯇][center]
[size=128]🌀[/size][/center]
⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ ⸻ [/spoiler][/td][td]                                  [/td][/tr][/table][hr][table][tr][td][spoiler=🐘↗][url=https://*]🡒 Choose 🐘 server. 🡐[/url][/spoiler][/td][td][spoiler=🄵 ⇄ 🄵]All Friendica servers use the same alphanumeric string to identify a specific post, so you can switch to another Friendica server simply by replacing the domain part (such as [i]libranet.de, venera.social, loma.ml, trom.tf,[/i] etc.) of the URL in your browser's search bar with the domain of the other Friendica server.[/spoiler][/td][td]                                                          [/td][td][spoiler=𝙱𝙱𝙲𝚘𝚍𝚎]~[/spoiler][/td][/tr][/table][hr][table]
/*
epilogue
*/
[/table]

[table][tr][th][spoiler=🧭][center][size=60]🧭[/size]
[h2]Portal Navi­ga­tion[/h2][/center][/spoiler][/th][th][spoiler=✏][center][size=60]✏[/size]
[h2]Blog Col­lec­t­ive[/h2][/center][/spoiler][/th][th][spoiler=⚖️][center][size=60]⚖️[/size]
[h2]The Rules[/h2][/center][/spoiler][/th][th][spoiler=❓][center][size=60]❓[/size]
[h2]FAQ[i]’s[/i][/h2][/center][/spoiler][/th][th][spoiler=✖][center][size=60]✖[/size][h2]Infre­quen­t­ly Ask­ed Q[i]’s[/i][/h2][/center][/spoiler][/th][td][/td][/tr][/table]

@Pat Not complaining. Trying to plan ahead.

I am quite happy with the 600 I follow. Also, I am NOT complaining about the new people that have come after me or those that might come in the future.

This issue is not about being overwhelmed, but about the inevitable structural changes that happen with growth.

Sure, I have been here only 5 weeks, but my instance has undergone 160% growth since then, because it is great place. in general has had only 30% growth. I am on an outlier .

How big is too big, and should we be proactive?

Is something inherent lost *whenever* a goes large?

(The advantages are obvious, but perhaps the disadvantages, though hidden, are just as bad.)

At what size does inevitably become corporate in character, despite all intentions?

Should there be deliberate intentional deconstruction into smaller instances at some point, and explicitly planned?

-adjacent issue.

@Beaglehaus

Sadly, I was still under the influence of my libertarian step-father Mike, and I voted for Reagan. Mike has since fallen off the far-right cliff. 😬

Personally I find 'blocking an instance because they won't block /any/ other instance' big bullshit :nkoFacepalm:

First of all, you don't get to dictate the rules on any others instance to begin with and secondly why should you be bothered by this?

If you block that /any/ instance it's done and you won't see stuff for it anymore but stop shaming others for not making the same decision, that's very childish

"I block you because you won't block them" <-- ignore that bullshit please

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