Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
NB I hadn't realised that @biorxivpreprint also incorporated the possibility of adding a graphical abstract to the preprint page, kudos to @richardsever et al
I spoke with the senior author, Matteo Iannacone of #SanRaffaele in Milan for the #EMBOPodcast earlier this year about models for #SarsCov2 research, including dramatic differences between aerosol vs intranasal exposure to the virus in mice - the #pathogenesis of the disease is very different.
https://www.embo.org/podcasts/embo-young-investigators-past-and-present/
'SARS-CoV-2 infection has caused a major global burden. Despite intensive research, the mechanism and dynamics of early viral replication are not completely understood including the kinetics of formation of plus stranded genomic and subgenomic RNAs (gRNA and sgRNA) starting from the RNA from the first virus that enters the cell. We employed single-molecule RNA-fluorescence in situ hybridization (smRNA-FISH) to simultaneously detect viral gRNA and sgRNA in infected cells and carried out a time course analysis to determine the kinetics of their replication.'
'En la ficha de la casa de subastas se especifica que la pieza, sin marco, es posterior al artista renacentista. Una serie de características que, a priori, parecen más disuasorias que atractivas. Pero, tras 11 días expuesta en la web de Christie´s, el último día se produjo una batalla entre unos pocos comerciantes. En minutos, las ofertas fueron escalando y el precio se disparó hasta más de un millón de euros. ¿Qué pasó? ¿Por qué una copia posterior a Leonardo da Vinci llegó hasta esa cantidad? Una vez más, como todo lo que rodea al pintor y a este cuadro, hay más misterios que certezas.'
I love footnotes. This one about "Invasion of the Body Snatchers" from Quentin Tarantino's 'Cinema Speculation' is straight out of a seminar on consciousness
That's how you start an abstract:
"In the beginning it was simple: we injected a protein antigen and studied the immune responses against the purified protein. This elegant toolbox uncovered thousands of mechanisms via which immune cells are activated. However, when we consider immune responses against real infectious threats, this elegant simplification misses half of the story: the infectious agents are typically evolving orders-of-magnitude faster than we are."
"Olfaction is at once both the primitive sensory modality and one of the hardest to understand, in large part due to the complexity of olfactory stimulus space. Whereas light and sound are easily ordered along natural physical axes that are reflected in their respective sensory codes, the organizational axes of odor space are not obvious."
Barnum & Hong Primer on olfactory coding @CurrentBiology
https://www.cell.com/current-biology/fulltext/S0960-9822(22)01753-5
“Los escritores no tienen que ser profesores de moral, pero tienen que expresar la condición humana. Y nada es más esencial, para todos los hombres y en todos los instantes, que el bien y el mal”. La frase pertenece a un artículo de Simone Weil. Tiene 32 años y ya lleva algunos meses en Marsella, transformada en ciudad de paso para miles de europeos que escapaban del nazismo.'
'In #malaria parasites, sexual reproduction coincides with transmission to the vector host. Sex determination is non-genetic, with each haploid parasite capable of producing either a male or a female gametocyte in the human host. The hierarchy of events and molecular mechanisms that trigger sex determination and maintenance of sexual identity are yet to be elucidated.'
#Plasmodium
"Together with other Africa-derived BA.1-like sequence entries, the Omicron ancestors clustered in basal sister relationship between the Omicron clade sensu strictu, the BA.1 sublineage and Omicron ancestors belonging to the globally circulating B.1 lineage (Fig. 3, A and B). Phylogeographic analyses supported BA.1 origins in Western Africa preceding spread in Southern Africa (fig. S4), which was consistent with the PCR-based data (table S2)."
https://www.science.org/doi/10.1126/science.add8737#.Y4kAlP7cJtw.twitter
'What types of responses can occur transgenerationally? Can the brain coordinate these responses?'
Throwback to the Fall of 2021, the second #EMBOPodcast with @Odedrechavi "Physiologically Irreverent"
"Taken together, beyond revealing the central role of cristae architecture to prevent mtDNA release and inflammation, our results mechanistically link mitochondrial cristae disorganization and inflammation, two emerging hallmarks of aging and aging-related degenerative diseases."
#mitochondria #inflammation #InnateImmunity #Immunology
He et al @CellReports
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01657-6
'Sadly, my colleagues and I were to become far more familiar with life-threatening parasitic infections. In the early years of the aids epidemic, I lost many of my patients to them. An aids patient’s devastated immune system might allow the parasite Toxoplasma gondii, carried by cats, to form brain abscesses; Cryptosporidium infection, which normally infests cattle, caused wasting from relentless diarrhea.'
https://www.newyorker.com/magazine/2022/12/12/in-praise-of-parasites
Gathering real world data on the efficacy of drugs and vaccines used to treat or prevent #monkeypox is vital. Many where developed for #smallpox and approved via the FDA's "animal rule", which means that although the safety data is there, the efficacy is essentially unknown. I wrote a bit about this for #NatureMedicine in September when looking at the use of the #antiviral #tecovirimat for monkeypox.
Great (and brief, 12m) video at @aeon_co on Hopper and movies
Great animation over at @aeon_co
'Growing up in the 1940s, Ronald Clark had an experience that sounds as if it was plucked from a children’s book – he lived in a New York City public library. And indeed, he believed that living in this ‘temple of knowledge’, where his father worked as a custodian, was a grand privilege, even as it led to feelings of difference among his peers'
'A paper published last month in the journal Frontiers in Ecology and Evolution argues that the appetite of the Steller’s sea cow played a major role in shaping coastal ecosystems in northern Pacific waters, particularly the kelp forests that have been devastated in recent years by factors linked to climate change. The paper claims that the sea cow would have made kelp forests more resilient to these changes, and that conservationists may be able to use this knowledge to better protect such ecosystems in the future.'
https://www.nytimes.com/2022/12/05/science/sea-cow-california-kelp.html
'In this issue of EMBO Molecular Medicine, Zeller et al report development of a novel low molecular weight phosphocholine-mimetic that binds to pCRP and inhibits conformation change-mediated expression of pro-inflammatory actions without impairing its defense function and demonstrate its beneficial actions in preventing rejection of allograft transplants and renal ischemia–reperfusion injury.'
@EmboMolMed
"A close examination of the IL-2–IL-2Rα binding interface reveals a putative “pH Switch” consisting of the interaction between Arg38 in IL-2 and His120 in IL-2Rα (Fig. 2F). We hypothesized that, at the low pH in the TME, His120 would become protonated, resulting in release of IL-2 from IL-2Rα and therefore lack of signaling."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
