Marco Radi @marcoradi@qoto.org

An interesting point on #drugdiscovery
“.... How do we truly define a #smallmolecule #drug today? ... Are #chemists making the “wrong” kinds of molecules?
Or have we entered a new era of drug modalities?
.... And just to prove chemists can continue to make the “right” kinds of molecules, here are some recent low Mw drug #approvals -
-       Tecfidera (Mw 144), #FDA approved 2013
-       Tavaborole (Mw 151), FDA approved 2014
-       Avibactam (Mw 265), FDA approved 2015
-       Benznidazole (Mw 260), FDA approved 2017
-       Migalastat (Mw 163), FDA approved 2018
 
How many novel small molecule drugs Mw<300 are yet to be discovered?”

https://www.linkedin.com/posts/trevor-brett-a09721131_medicine-pharmaceuticals-healthcare-activity-7003780928837672960-lqc1?utm_source=share&utm_medium=member_ios

A fantastic #review on #lipidkinases by John #Burke and colleagues.
#PI3K #PI4K #PIKfyve
https://www.nature.com/articles/s41573-022-00582-5

Base-modified #nucleosides as potent #antiviral agents against #EV71
https://www.sciencedirect.com/science/article/pii/S0223523422008443

@soragnilab
indeed it is!!

Dear @biorxivpreprint, if you don't use #hashtags in your #toots, it is hard to find your #contents in #mastodon

An excellent #Review by Jacob #McPhail and John #Burke on the #PI4K #kinase role in #viral #replication.
https://onlinelibrary.wiley.com/doi/full/10.1111/tra.12841

As additional Appendix to my #introduction, I would like to #boost our recent #DrugDiscovery efforts in the field of #CysticFibrosis: we have developed #MultiTarget compounds acting at the same time as #CFTR #Correctors and #Antibacterials or #Antivirals depending on the specific functionalization of the same chemotype.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202200277
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01416

As second Appendix to my #introduction, I would like to #boost our recent #DrugDiscovery efforts in the development of #BroadSpectrum #Antivirals.
#SarsCov2 #ZIKV #Rhinovirus #enterovirus

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202100483

As appendix to my #Introduction and catalyst for possible collaborations in the field, I would like to #boost our recent #DrugDiscovery effort in the modulation of the #CCL20/#CCR6 axis to identify new #inhibitors for #IBD and other #diseases depending on the same axis.

https://www.sciencedirect.com/science/article/abs/pii/S0223523422006055

An excellent overview on #coxsackievirus targeting drugs.
https://onlinelibrary.wiley.com/doi/epdf/10.1002/rmv.2406

Another excellent business opportunity for our birdy-friend: https://pubs.acs.org/doi/10.1021/cen-10040-cover

Possible applications of #MultiTarget compounds in #ProxPharm Beyond PROTACs.

https://www.sciencedirect.com/science/article/pii/S2001037022005049

-Time for a short #Introduction-

I am a group leader in #MedicinalChemistry at the University of Parma. My lab combines #chemical & #computational techniques to develop novel pharmacological tools to study different Chronic Diseases (#CysticFibrosis, #IBD, #Hypercholesterolemia, #Alzheimer, #Cancer) and Infective Agents (#SARSCoV2, #Enterovirus, #Flavivirus, #Monkeypox, #HIV).
We are particularly interested in the development of #MultiTarget inhibitors and open to new #collaborations in #DrugDiscovery.
#Tooting (sooner or later) about the #chemistry and #science