Marco Radi @marcoradi@qoto.org
- Research
- Drug Discovery and Medicinal Chemistry.
Professor of Medicinal Chemistry at the University of Parma (Italy).
Developing novel drug candidates for Chronic and Infective Diseases.
Interests:
#MedChem #MedicinalChemistry #DrugDiscovery #Chemistry #MultiTarget #Antiviral #Antibacterial #Anticancer #IBD #CVD #Alzheimer #CysticFibrosis #Medicine #Pharmacology #Biotech #ccr6 #pcsk9 #bsaa
Joined Nov 2022
Marco Radi
boosted
WHO reports on a #Nipah virus outbreak in Kerala, India. Six cases to date, 2 dead. The exposure route for index case (dead) is unknown, but the second fatal case was infected at the hospital. There are no vaccines to prevent Nipah and no drugs; supportive care used. https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON490
Marco Radi
boosted
Wow. Ok. Normally I feel like it's a bit overplayed to individually comment on #MDPI or the whole #AcademicChatter conversation, but this is really a must-see:
A Special Issue where the guest editors are lead or senior author on 27 of the 28 papers published through it. Were they also their own reviewers!? Like... that sounds like I'm taking the piss, but... no seriously were they?
https://www.mdpi.com/journal/processes/special_issues/Biologics_Botanicals
I guess this is a preview to an upcoming post. Look forward to it...
A #mentor who doesn't find time to correct trainees' writings (paper, thesis..) or delegate this kind of duty, is not mentoring you.
⚠️Warning signs: has no time for discussion or reads email when spoken to, unreachable when away, doesn't share info, says "me" instead of "us"
🔴A strong case for a long-hanging question!
A monumental #DrugDiscovery #perspective on #JMedChem.
Well done @arash4sadri 👏
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01737?ref=pdf
Submitted a #manuscript to an #Elsevier journal that brags 4 weeks of reviewing time: no feedback after three months, no replies to author's query email or from customer support and no possibility to unsubmit the manuscript.
Anyone with a similar experience?
"eHydrogenation:Hydrogen-free Electrochemical Hydrogenation!" by Kevin Lam et al. (@kevin) published in #Angewandte #Chemie. A practical and selective #electrochemical #hydrogenation and #deuteration (using D2O)! #openacces #chemistry #electrochemistry
https://onlinelibrary.wiley.com/doi/10.1002/anie.202309563
#Click #electrochemistry for the rapid modification of virus, bacterial and cell surfaces by Gouin Sebastien et al on #Nature #Communications https://www.nature.com/articles/s41467-023-40534-0.epdf?sharing_token=OsorvNCu4Dj2W8fEWjiX5NRgN0jAjWel9jnR3ZoTv0OkDjrrak_6vx-dAvbDcyZ3cXUi4a566YU_F8_4kqBUHQX1uGPIOvWqTjE2TLhmzCkk6pVMClBhNeLzBGxFusztvHgkCMpFZYPjkQH3T83mMMDsc01RfBwxbc7Ft61LbWw%3D
Marco Radi
boosted
A company developing a drug delivery process with treatments activated by ultrasound received an option to license a key technology from its founders' university labs.
https://sciencebusiness.technewslit.com/?p=45126
#News #Press #Science #Business #Biotechnology #IntellectualProperty #Option #Licensing #MaterialsScience #Ultrasound #Chemistry #Physics #University #Capsules #NucleicAcids #Biologics
Marco Radi
boosted
Chung K. Chu and colleagues from #Georgia University (#Athens #USA) published in the Journal of Medical Chemistry the synthesis and biological evaluation of several prodrug strategies for l-BHDU against Varicella Zoster Virus. #antivirals #chemistry #medchem
Something to try for a change...
#multitasking #research #grant #proposal
Nothing new under the sun, but it is always interesting to see how deep the rabbit hole goes....
#publishorperish #mdpi #pyramidscheme #metrics #impactfactor
https://english.elpais.com/science-tech/2023-06-04/a-researcher-who-publishes-a-study-every-two-days-reveals-the-darker-side-of-science.html
Marco Radi
boosted
#IDMastodon #Viralimmunology @cellpress it is unsettling to learn that #SarsCoV2 has an alternative way it infects the host cells by using a lysosomal transmembrane protein, can serve as an alternative receptor for SARS2 entry into ACE2-negative cells. Spike mute E484D increased TMEM106B binding, thereby enhancing TMEM106B-mediated entry
https://www.cell.com/cell/fulltext/S0092-8674(23)00645-1
Marco Radi
boosted
Design of CD73 #inhibitor|s
Introduction of 3' alkynyl moiety led to drastically improved antitumor activity. E. B. Sjogren and colleagues from Calithera Biosciences described the synthesis of these orally available nucleoside analogues in the Journal of Medicinal #Chemistry.
“I believe that you discover what you screen for, so screen design is of paramount importance and the high content nature of a phenotypic screen maximizes the chance of success whilst also identifying novel MOAs that can be challenging to anticipate.”
https://link.springer.com/article/10.1007/s00044-023-03070-6
Have big Pharmas stopped innovating?
#Nucleoside #chemistry is where I started more than 20 years ago as a young MedChem student in the group of Maurizio Botta.
A back to the future adventure has brought us today to this new paper on #ChemMedChem.
We have tried to teach these old dogs new tricks for the development of #broadspectrum #antimicrobial agents.
#MedChem #DrugDiscovery #Antiviral
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300200
Call for proposals "MSCA@UNIPR BOOTCAMP 2023" – https://www.unipr.it/msca-bootcampunipr-2023 - aimed at selecting 20 postdoctoral researchers from all over the world who wish to submit innovative research projects for a Marie Skłodowska-Curie Actions Postdoctoral Fellowship.
Selected researchers will be eligible for a research grant up to 1,000 euro to participate in a training workshop that will be held in Parma from June 5th to June 7th, 2023.
- Research
- Drug Discovery and Medicinal Chemistry.
Professor of Medicinal Chemistry at the University of Parma (Italy).
Developing novel drug candidates for Chronic and Infective Diseases.
Interests:
#MedChem #MedicinalChemistry #DrugDiscovery #Chemistry #MultiTarget #Antiviral #Antibacterial #Anticancer #IBD #CVD #Alzheimer #CysticFibrosis #Medicine #Pharmacology #Biotech #ccr6 #pcsk9 #bsaa
Joined Nov 2022
